Precursor B-cell lymphoblastic leukemia

Precursor B-cell lymphoblastic leukemia
Classification and external resources
ICD-O: M9836/3
MeSH D015452

Precursor B-cell lymphoblastic leukemia is a form of lymphoid leukemia, sometimes additionally classified as a lymphoma, as designated leukemia/lymphoma.

It consists of the following subtypes:[1]

Molecular Mechanisms

One interesting model of precursor B ALL shows aberrant function of a single gene, namely Pax5, as capable to change phenotype of B cells toward precursor cells.[2][3]

References

  1. ^ Randolph TR (2004). "Advances in acute lymphoblastic leukemia". Clin Lab Sci 17 (4): 235–45. PMID 15559730. http://findarticles.com/p/articles/mi_qa3890/is_200410/ai_n9429273/pg_2. 
  2. ^ Carotta S, Nutt SL (March 2008). "Losing B cell identity". Bioessays 30 (3): 203–7. doi:10.1002/bies.20725. PMID 18293359. 
  3. ^ Den Boer ML, van Slegtenhorst M, De Menezes RX, et al. (February 2009). "A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study". Lancet Oncol. 10 (2): 125–34. doi:10.1016/S1470-2045(08)70339-5. PMC 2707020. PMID 19138562. http://linkinghub.elsevier.com/retrieve/pii/S1470-2045(08)70339-5.